In this article, we will consider a guide to uninstall Skype for Business for both Windows and Mac OS users.
Step 1. Disabling Automatic Startup of Skype for Business
1) In Skype for Business, click the settings icon and select Tools > Options.
2) Choose Personal, then uncheck the boxes for Automatically start the application when I log on to Windows and Start the application in the foreground. Then click OK.
3) Select File > Exit.
The Skype for Business application will remain on your computer but will no longer start automatically.
Step 2. Uninstalling Skype for Business from Your Computer
Attention! If you are using the Microsoft 365 version of Skype for Business, you cannot uninstall it from your computer without removing other Office applications. This is because it is integrated with other Office applications. The following instructions are for users with standalone versions of Skype for Business.
1) Choose Control Panel > Programs > Programs and Features > Uninstall or change a program.
2) Select Skype for Business > Uninstall. If you do not see Skype for Business in the list, it means you are using the version integrated with other Microsoft 365 applications. The only way to remove this version is to uninstall all Office applications from your computer.
3) In the “Continue?” dialog, select Uninstall.
4) After the uninstallation process is complete, click Close.
If the above instructions did not help, try disabling the application in the registry.
1) To remove the Skype for Business icon
from the dock, quit the Skype for Business application on Mac. 
2) Close the Skype for Business login page on Mac.
3) Press the Control key and click 
simultaneously. Choose Quit.
4) Choose Finder > Applications. Scroll to the Skype for Business application and drag it to the trash.
